Comprehensive Cardiomyopathy Panel

Cardiomyopathy

What is Cardiomyopathy?

Cardiomyopathy is a disease of the heart muscle. Patients with cardiomyopathy have abnormal heart muscles, which makes it difficult for the heart to pump blood to parts of the body, and can result in heart failure.

There are different conditions that cause cardiomyopathy, such as dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and left ventricular non-compaction (LVNC).

What causes Cardiomyopathy?

Causes of cardiomyopathy are varied – some are caused by gene mutations, while other non-genetic factors could include viruses and certain medications.

The genetic causes of some types of cardiomyopathy can be sporadic, where a new mutation occurs in a patient with no other family members known to be affected, making them the first person in the family to be diagnosed with the disease. There are also familial causes of cardiomyopathy, where a positive family history indicates an underlying genetic cause. In familial cardiomyopathy, there is a 50 percent chance of the condition being passed down to the next generation.

Why test for Cardiomyopathy?

Cardiomyopathy can run in the family, with mutations in over 100 genes linked to familial cardiomyopathy.

Genetic testing for your cardiomyopathy can benefit you and your family by confirming a diagnosis of a genetic cardiomyopathy. Test results can assist with decisions about treatment for your condition. It can also identify family members who are at risk of developing cardiomyopathy so they can seek preventative care.

Comprehensive Cardiomyopathy Panel

We offer a Comprehensive Cardiomyopathy Panel, which includes multiple genes that cause cardiomyopathy. With many genes included in the panel, it provides comprehensive results that can be useful in clarifying the type and cause of cardiomyopathy. However, the large number of genes tested may also result in previously unreported DNA differences of unknown clinical significance being identified too.

How does it work?

The Comprehensive Cardiomyopathy Panel is a blood test ordered by your physician. Your DNA is extracted from the blood and analyzed by searching specifically for mutations in any genes that are associated with cardiomyopathies. The test takes approximately 10 weeks to complete, and the results will be sent to your physician, who will explain the test results to you.

We will need two tubes of blood (about 7 to 10ml) and a signed consent form from you to send to the laboratory. We recommend genetic counselling before genetic tests are ordered to discuss the implications of the testing and potential results.

If you would like more information or advice on any of our tests and services, please contact us at +65 6336 2050 or info@asia-genomics.com.