Hereditary Breast and Ovarian Cancer Panels
Hereditary Breast and Ovarian cancer (HBOC) refers to a pattern of breast and ovarian cancers due to inheritance of susceptibility genes. This is an autosomal dominant condition, where a mutation in one copy of the gene causes an increased risk for the condition, and there is a 50 percent chance of inheriting the mutation from parents.
The fifth most common cancer in Singaporean women, ovarian cancer refers to malignant growths of the ovaries. This condition has a high mortality rate as most ovarian cancers are diagnosed at a late stage. Epithelial ovarian cancer is the most common form of ovarian cancer, and up to 25 percent of ovarian cancers may have a hereditary basis.
Why get tested for Hereditary Breast and Ovarian Cancer?
If there is a family history of HBOC, genetic testing can help identify your risks for such cancers, along with learning about such risks for other family members and future generations. This could help you make informed decisions about your future, including taking steps to reduce your cancer risks.
Who should get tested for Hereditary Breast and Ovarian Cancer?
It is recommended that individuals with a personal and family medical history with the following should consider genetic testing for HBOC susceptibility genes:
- Breast cancer first diagnosed at a young age (below 45 years of age).
- Bilateral breast cancer.
- Multiple cancer types in an individual.
- Many blood relatives across multiple generations affected by related cancers such as breast, ovarian, pancreatic and prostate cancer.
- Unusual cancers such as Male breast cancer.
- A pattern of cancer typical of known cancer predisposition syndrome.
Tests for Hereditary Breast and Ovarian Cancer
Asia Genomics offers three genetic tests to screen for HBOC:
HBOC High Risk Genes Test
Apart from BRCA1 and BRCA2, there are a number of gene mutations that also pose high risk to HBOC. Mutations in these high risk genes increase the lifetime cancer risks of carriers by up to 50 percent, or four fold, as compared to the normal population.
The HBOC High Risk Genes Test usually identifies mutations in the BRCA1, BRCA2, CDH1, PTEN, TP53 and STK11 genes. It is a blood test ordered by your physician. Your DNA is extracted from the blood and analyzed. The test takes approximately four weeks to complete, and the results will be sent to your physician, who will explain the test results to you.
We will need two tubes of blood (about 4ml each) and a signed consent form from you to send to the laboratory. We recommend genetic counselling before genetic tests are ordered to discuss the implications of the testing and potential results.
HBOC Comprehensive Multigene Panel
There are other HBOC susceptibility genes in addition to the high risk ones mentioned above. There are 17 moderate and low risk genes. Similar to the BRCA genes, carriers of such genes are also at risk to other cancer types such as pancreatic, biliary tract, small bowel, colorectal and brain cancer, among others.
The HBOC Comprehensive Multigene Panel identifies mutations in all high, moderate and low risk genes. It is a blood test ordered by your physician. Your DNA is extracted from the blood and analyzed. The test takes approximately four weeks to complete, and the results will be sent to your physician, who will explain the test results to you.
We will need two tubes of blood (about 4ml each) and a signed consent form from you to send to the laboratory. We recommend genetic counseling before genetic tests are ordered to discuss the implications of the testing and potential results.